Director of LNP Formulation

Newton, MA

Director of RNA Formulation 1287715

Location: Newton, MA (Hybrid)
Science: RNA focused therapy
Therapeutic Areas: Rare diseases and Complex Liver indications

Job Overview: This individual will oversee the formulation and process development of biologic dosage forms for in vitro and in vivo preclinical studies. The mission is to develop complex formulations for mRNA payloads with a goal of prolonged expression and immune evasion.

Responsibilities:

  • Primarily responsible for the production and characterization of mRNA delivery vehicles (lipid based, polymer based, or a hybrid of the two) as well as building the assay toolbox to understand the principles behind their delivery mechanism.
  • Formulation and characterization of LNP and nanoparticle delivery systems
  • Development and execution of cell-based and cell-free assays to understand structure-activity and structure-function of our delivery systems
  • Design and execution of experiments that elucidate the mechanism of LNP delivery to various tissues and cell types
  • Work cross-functionally with internal stake holders and effectively manage development activities through external vendors.

Qualifications:

  • PhD in Biochemical/Biomedical Engineering, Pharmaceutical Sciences, or related discipline with 5+ years of related industry experience or Masters with 8 years of related industry experience.
  • Experience in successfully leading drug product development activities for complex formulations including LNP 
  • Experience in development of extended-release formulations is ideal
  • Knowledge of current regulatory guidance and experience in managing IND/IMPD and BLA filings
  • Versatile, driven and curious to take on new and challenging roles and responsibilities
  • History successfully developing biologics drug product formulations and processes from concept to late-stage development across multiple modalities.

To find out more about this job and our clients company culture, please call us direct at 603-766-0600.

About Stratacuity:

Whether you are seeking a career change or simply interested in becoming part of our network, you will appreciate the ethics guiding each Stratacuity team member. We build lasting relationships with exceptional biopharmaceutical talent and take great care to protect your personal information. Upon receiving your inquiry, you may be directly contacted by a Stratacuity team member to discuss your career goals. We will not share your information with anyone without your direct prior consent.

PROVEN SCIENTIFIC PLACEMENT™

Stratacuity is an Equal Employment Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Stratacuity will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact us.

jditalia@stratacuity.com

Code: TechOps

 

 

 

 

 

 

 

 

EEO Employer

Apex Systems is an equal opportunity employer. We do not discriminate or allow discrimination on the basis of race, color, religion, creed, sex (including pregnancy, childbirth, breastfeeding, or related medical conditions), age, sexual orientation, gender identity, national origin, ancestry, citizenship, genetic information, registered domestic partner status, marital status, disability, status as a crime victim, protected veteran status, political affiliation, union membership, or any other characteristic protected by law. Apex will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact our Employee Services Department at employeeservices@apexsystems.com or 844-463-6178.