Head of DMPK
Head of DMPK 1330375
Location: Boston, MA (Hybrid)
Science/ Focus: Precision Medicine
Therapeutic Area: Oncology
Job Focus: A successful candidate will be responsible for designing, implementing, and interpreting in vitro and in vivo studies to understand adsorption, distribution, metabolism, and excretion (ADME) as an integral part of the drug discovery team, to drive to development candidate selection and into clinical development.
Responsibilities:
- Lead overall scientific, technical, and operational efforts supporting DMPK across the project portfolio
- Provide scientific guidance on lead optimization and work in close collaboration with colleagues to optimize and evaluate the DMPK properties of candidate drugs
- Define appropriate strategies, design internal/external DMPK studies and be responsible for oversight and deliverables from external studies
- Ensure complete preclinical assessment of the ADME properties of lead molecules and development candidates
- Responsible for assembling IND enabling preclinical PK packages to make evidence based clinical dose projections
Qualifications:
- Ph.D. with 10+ years of extensive training and industry experience in bioanalysis, metabolism, and pharmacokinetics in the context of drug discovery project teams
- A strong background in DMPK and pharmacokinetics/pharmacodynamics as applied to small molecule drug discovery and experience with covalent-drug molecules
- Extensive knowledge of metabolic routes of biotransformation, metabolite identification, and the chemistry of drug metabolism are required
- Technical knowledge in multiple DMPK areas and an in-depth understanding of the experimental DMPK methodologies and approaches utilized in optimizing the ADME properties of small-molecule oral drugs
About Stratacuity:
Whether you are seeking a career change or simply interested in becoming part of our network, you will appreciate the ethics guiding each Stratacuity team member. We build lasting relationships with exceptional biopharmaceutical talent and take great care to protect your personal information. Upon receiving your inquiry, you may be directly contacted by a Stratacuity team member to discuss your career goals. We will not share your information with anyone without your direct prior consent.
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