Principal Scientist Translational Biology

Redwood City, CA

Our Client is a leading protein engineering company working on advancing protein optimization and production for clients across industries.

Responsibilities include:

  • Lead a talented group of PhD and non-PhD scientists responsible for the design, execution and data interpretation of all in vivo studies supporting the biotherapeutic research portfolio.
  • Lead multi-disciplinary project teams to discover, optimize and develop novel biotherapeutics in niche indications.
  • Play an active role in project inception and risk assessment.
  • Work effectively and in close partnership with leaders of other functional areas within and outside the biotherapeutic organization.
  • Develop sensitive and specific bioanalytical assays to accurately characterize drug PK, PK/PD and immunogenicity in multiple animal models.
  • Provide scientific leadership to the Translational Biology group and act as the point person for all non-regulated in vivo studies 
  • Generate data supporting development candidate nomination and work effectively with development teams to ensure smooth transitions of assets from research to development.   
  • Identify, develop, and manage external collaborators (academic, industrial partners, and CROs) to advance project needs.
  • Work closely with leaders and scientists from other departments and ensure full integration of his/her team within the overall organization.
  • Ensure clear and effective oral and written communication of plans, results and ideas with R&D, senior leadership, and external collaborators.
  • Provide hand-on training to junior staff as well as to external collaborators when needed.
  • Apply highest standards for data quality and analytical tools and use effective informatics tools for data visualization and communication.

Job Requirements:

  • Ph.D. in Pharmacology, Physiology or related fields and/or D.V.M. with a minimum of 12 years of biotech/pharma industry experience.
  • Proven track record of management of PhD level scientists in an industry setting.
  • Highly proficient in in vivo study design to assess efficacy, safety, PK, PD and immunogenicity of biotherapeutic proteins in healthy animals and disease models as evidenced by track record of publications in top tiered peer-reviewed scientific journals.
  • Demonstrated contributions to advancing lead molecules to clinical candidate nomination on multiple programs.
  • Significant experience developing, optimizing and running quantitative state-of-the art bioanalytical assays using multiple technology platforms.  
  • Key contributor to lead discovery and optimization strategies in relevant therapeutic areas.
  • Ability to troubleshoot technical and operational issue related to in vivo studies and bioanalytical assays.
  • Ability to adapt, learn, and provide methods, analyses, materials, services in a fast paced environment.
  • Effective communication (oral and written), documentation (record keeping, lab notebook, reports, SOPs), organization, and interpersonal skills.
  • Attention to detail, safety, and good laboratory practice.

 

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EEO Employer

Apex is an Equal Employment Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Apex will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact our Employee Services Department at employeeservices@apexsystemsinc.com or 844-463-6178.