Sr. Scientist, TCR Immunology

Cambridge, MA

Senior Scientist, TCR Immunology 1103974 

Job Scope and Purpose: 

We are seeking a talented and highly motivated Senior Scientist to join our client in the discovery of disease relevant immune synapses. The candidate will lead a team of junior scientists and will be responsible for development, standardization, automatization and deployment of techniques for prioritization of therapeutically-relevant targets. Data generated by the group will drive the development of therapies to make a meaningful difference for patients suffering from cancer or autoimmune diseases.

This position will report to the Director, Immunology and will be part of a matrixed team which includes colleagues from Immunology, Platform technologies, Computational biology, and Protein engineering teams.  Excellent communication skills, ability to work in a fast-paced environment and adapt to evolving priorities are a must. 

Primary Job Responsibilities:

  • Lead the recombinant TCR team. The candidate will be responsible for program related, scientific and operational objectives.
  • Establish, optimize and qualify assays for confirmation and prioritization of target antigens and TCRs
  • Streamline and automate approaches
  • Work closely with program teams, including Autoimmunity and Oncology Team
  • Work with and guide more junior researchers to design disease- and program-relevant experiments and strategies
  • Provide scientific, project and laboratory leadership to junior scientific staff
  • Analyze, summarize and communicate data to the leadership and project teams
  • Collaborate closely with Platform Technology and Computational Biology
  • teams for smooth and swift execution of discovery and translational medicine programs

Primary Job Requirements:

  • Ph.D. in Molecular Biology, Immunology or similar field with minimum of 5 years working experience in academia or industry.
  • In depth knowledge of TCR and recombinant TCR systems, including viral and non-viral transfers
  • In depth knowledge of molecular biology, design of transgene constructs, cloning and expression of the transgene in primary human cells and in cell lines
  • Experience with TCR sequencing
  • Working knowledge of T cell immunology, including laboratory techniques related to assessment of T cell function and specificity
  • Experience with multi-color flow cytometry for T cell characterization. Experience with T cell-based assays such as MHC/peptide tetramer, ELISpot, Luminex, and cytotoxicity
  • Experience with automatization is a strong plus
  • Highly adaptable and responsive to evolving strategic, technical and business opportunities
  • Excellent attention to detail, excellent written and oral communication skills
  • Proven track record of being personable, energetic, accountable, and an effective communicator
  • Must work well independently as well as an integral part of the team

About Stratacuity:

Whether you are seeking a career change or simply interested in becoming part of our network, you will appreciate the ethics guiding each Stratacuity team member. We build lasting relationships with exceptional biopharmaceutical talent and take great care to protect your personal information. Upon receiving your inquiry, you may be directly contacted by a Stratacuity team member to discuss your career goals. We will not share your information with anyone without your direct prior consent.
PROVEN SCIENTIFIC PLACEMENT™

 

Stratacuity is an Equal Employment Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Stratacuity will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact us.

 

atemple@stratacuity.com

 

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EEO Employer

Apex Systems is an equal opportunity employer. We do not discriminate or allow discrimination on the basis of race, color, religion, creed, sex (including pregnancy, childbirth, breastfeeding, or related medical conditions), age, sexual orientation, gender identity, national origin, ancestry, citizenship, genetic information, registered domestic partner status, marital status, disability, status as a crime victim, protected veteran status, political affiliation, union membership, or any other characteristic protected by law. Apex will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact our Employee Services Department at employeeservices@apexsystemsinc.com or 844-463-6178.